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Original Research

Preventive effect of pomegranate juice on ESWL-related renal damage in patients with kidney stones


1  Antalya Training and Research Hospital, Department of Urology, Antalya, Turkey
2 Live Hospital Beşiktaş, Department of Urology, İstanbul, Turkey
3 Bakırköy Dr. Sadi Konuk Training and Research Hospital, Department of Urology, İstanbul, Turkey

ABSTRACT

Objective: We aimed to show whether the antioxidant properties of pomegranate juice (PJ) show a protective effect against renal damage as-sociated with oxidative stress caused by Extracor-poreal Shock Wave Lithotripsy (ESWL) in patients who have undergone ESWL for kidney stones. 

Material and Methods: Ninety patients who were to undergo ESWL for kidney stones were in-cluded in the study and were divided into 3 groups with 30 patients each ESWL. Group 1 (control group) patients received only ESWL treatment. Group 2 (study group) patients were recommend-ed to take 30 ml/kg/day pomegranate juice mix-ture orally for 2 days before ESWL. Group 3 (pla-cebo group) patients were recommended to take 30 mg/kg/day water orally for 2 days before ESWL. All ESWL-treated patients received 2000 to 2500 shock waves at 18 to 24 in order to measure lipid peroxidation markers showing the DNA lesion as-sociated with oxidative stress and to show tubular damage after ESWL, 

Results: There was a statistically significant mean increase of 52.39± 10.49 in 8-Hydroxy deox-yguanosine (8-OHdG) levels after treatment com-pared to pre-treatment levels in Group 1 (p<0.01). There was a statistically significant mean increase of 13.16±7.71 and 33.24±12.82 in Groups 2 and 3, respectively (p<0.01; p<0.01, respectively) There was a statistically significant mean increase of 19.20±5.21 in N-acetyl-beta-D-glu-cosaminidase (NAG) levels after treatment com-pared to pre-treatment levels in Group 1 (p<0.01).There was a statistically significant mean increase of 3.44±5.21 and 13.07±5.50 in Groups 2 and 3, respectively (p<0.01; p<0.01, respec-tively).

Conclusion: Our study concluded that pomegranate juice (PJ) has protective effects against ESWL-related renal damage.

Keywords: Antioxidant, kidney stones, lithotripsy, pomegranate juice.


ABSTRACT

Objective: We aimed to show whether the antioxidant properties of pomegranate juice (PJ) show a protective effect against renal damage as-sociated with oxidative stress caused by Extracor-poreal Shock Wave Lithotripsy (ESWL) in patients who have undergone ESWL for kidney stones. 

Material and Methods: Ninety patients who were to undergo ESWL for kidney stones were in-cluded in the study and were divided into 3 groups with 30 patients each ESWL. Group 1 (control group) patients received only ESWL treatment. Group 2 (study group) patients were recommend-ed to take 30 ml/kg/day pomegranate juice mix-ture orally for 2 days before ESWL. Group 3 (pla-cebo group) patients were recommended to take 30 mg/kg/day water orally for 2 days before ESWL. All ESWL-treated patients received 2000 to 2500 shock waves at 18 to 24 in order to measure lipid peroxidation markers showing the DNA lesion as-sociated with oxidative stress and to show tubular damage after ESWL, 

Results: There was a statistically significant mean increase of 52.39± 10.49 in 8-Hydroxy deox-yguanosine (8-OHdG) levels after treatment com-pared to pre-treatment levels in Group 1 (p<0.01). There was a statistically significant mean increase of 13.16±7.71 and 33.24±12.82 in Groups 2 and 3, respectively (p<0.01; p<0.01, respectively) There was a statistically significant mean increase of 19.20±5.21 in N-acetyl-beta-D-glu-cosaminidase (NAG) levels after treatment com-pared to pre-treatment levels in Group 1 (p<0.01).There was a statistically significant mean increase of 3.44±5.21 and 13.07±5.50 in Groups 2 and 3, respectively (p<0.01; p<0.01, respec-tively).

Conclusion: Our study concluded that pomegranate juice (PJ) has protective effects against ESWL-related renal damage.

Keywords: Antioxidant, kidney stones, lithotripsy, pomegranate juice.

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